This article details development of the first large animal model of pancreatic carcinogenesis and may allow for insight into new avenues of translational research not before possible in rodents. By developing a porcine model via the Oncopig platform that closely mimics human pancreatic ductal adenocarcinoma (PDAC), researchers can now explore new treatment modalities, surgical interventions, and radiological techniques that were previously unfeasible in mouse models.