A Validated, Transitional and Translational Porcine Model of Hepatocellular Carcinoma
This article details a study validating the Oncopig model for hepatocellular carcinoma (HCC). Specifically, the article presents data demonstrating the ability of Oncopig HCC cell lines to recapitulate key features of human HCC, providing validation for the use of the Oncopig platform for human HCC research. This model will enable the testing of different HCC treatment techniques and the evaluation of histologic, radiographic, and pathological responses in a model more similar to human HCC than currently available small animal models.
Read articleOncopig Soft-Tissue Sarcomas Recapitulate Key Transcriptional Features of Human Sarcomas
Human soft-tissue sarcomas (STS) are rare mesenchymal tumors with a 5-year survival rate of 50%, highlighting the need for further STS research. Research has been hampered by limited human sarcoma cell line availability and the large number of STS subtypes, making development of STS cell lines and animal models representative of the diverse human STS subtypes critical. Pigs represent ideal human disease models due to their similar size, anatomy, metabolism, and genetics compared to humans.
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