Cancer is a global epidemic causing more than 8 million annual deaths worldwide. The more than 13 million new cancer diagnoses made each year carry an economic burden of $290B. Cancer is expected to be the second leading cause of death in the United States in 2017. The authors discuss how the Oncopig Cancer Model represents a significant breakthrough in cancer research, providing a powerful and clinically relevant tool to study cancer biology, test therapeutic interventions, and improve patient outcomes in the fight against cancer.