This article details a study validating the Oncopig model for hepatocellular carcinoma (HCC). Specifically, the article presents data demonstrating the ability of Oncopig HCC cell lines to recapitulate key features of human HCC, providing validation for the use of the Oncopig platform for human HCC research. This model will enable the testing of different HCC treatment techniques and the evaluation of histologic, radiographic, and pathological responses in a model more similar to human HCC than currently available small animal models.